Description
Integrin alpha 6 beta 1, also called platelet glycoprotein GPIc-IIa, is a receptor for laminin on platelets.
The ITGA6 protein product is the integrin alpha chain alpha 6.
Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain.
A given chain may combine with multiple partners resulting in different integrins.
For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6.
Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
ITGA6 has been shown to interact with TSPAN4 and GIPC1